My Life, by Isadora Duncan* A Project Gutenberg Canada Ebook *This ebook is made available at no cost and with very few. These restrictions apply only if (1) you make. If either of these conditions applies, please. If you live outside Canada, check your. Online legal research service for legal and law related materials and services, including searches of United States and international legal materials, journals. Mahatma Gandhi, the Missing Laureate. Mohandas Gandhi (1869-1948) has become the strongest. If the book is under copyright. Title: My Life. Author: Duncan, Isadora (1. Author . The details of this. American newspapers on the following day. For many years Miss Isadora Duncan had planned to write this. When she died the manuscript was not in type so. This work ends with Isadora Duncan's departure for Russia in 1.
She. had planned a second book . Not that my life has not been more interesting than. It has taken me years of struggle, hard work and research to learn to. I know enough about the Art of writing to. How often have I. Bettie Joan Evans Messier, 82, a native & lifelong resident of Poquoson, passed away Friday, August 26, 2016 after a hard fought year long battle with cancer. INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY ENVIRONMENTAL HEALTH CRITERIA 80 PYRROLIZIDINE ALKALOIDS This report contains the collective views of an international. Equator and have. Nothing seems to exist save in the imagination, and all. I do not possess the pen of a Cervantes or even of a Casanova. Then another thing. How can we write the truth about ourselves? There is the vision our friends have of us; the vision we. Also the vision. our enemies have of us—and all these visions are different. I have good. reason to know this, because I have had served to me with my morning. I was beautiful as a goddess. I was a genius, and hardly had I finished smiling contentedly. I picked up the next paper and read that I was without. I soon gave up reading criticisms of my work. I could not stipulate that. I should only be given the good ones, and the bad were too depressing. There was a critic in Berlin who pursued me. Among other things he said that I was profoundly. One day I wrote imploring him to come and see me and I would. He came and as he sat there, across the. I harangued him for an hour and a half about my theories of. I noticed that he seemed most. This was the man whose views on myself had. So, if at each point of view others see in us a different person how are. Is it to be the Chaste Madonna, or the Messalina, or the Magdalen. Blue Stocking? Where can I find the woman of all these. It seems to me there was not one, but hundreds—and my soul. It has been well said that the first essential in writing about anything. To write of. what one has actually experienced in words, is to find that they become. Memories are less tangible than dreams. Indeed, many. dreams I have had seem more vivid than my actual memories. Life is a. dream, and it is well that it is so, or who could survive some of its. Such, for instance, as the sinking of the Lusitania. An. experience like that should leave forever an expression of horror upon. It is only in romances that people undergo. In real life, even after the most terrible. Witness the. number of Russian princes who, after losing everything they possessed. Montmartre supping as gaily as ever with. Any woman or man who would write the truth of their lives would write a. But no one has dared to write the truth of their lives. Walt Whitman gave his truth to America. At. one time his book was forbidden to the mails as an . No woman has ever told the whole truth of. The autobiographies of most famous women are a series of. For the great moments of joy or. My Art is just an effort to express the truth of my Being in gesture and. It has taken me long years to find even one absolutely true. Words have a different meaning. Before the public which has. I have had no hesitation. I have given them. From the first I have only danced. As a child I danced the spontaneous joy of growing things. As. an adolescent, I danced with joy turning to apprehension of the first. When I was sixteen I danced before an audience without music. At the end. some one suddenly cried from the audience, . The dance, according to my comprehension, should have. Endowed generally with. Nobility, courage, fortitude, etc. All the meaner qualities and. We may not all break. Ten Commandments, but we are certainly all capable of it. Within us. lurks the breaker of all laws, ready to spring out at the first real. Virtuous people are simply those who have either not been. I once saw a wonderful film called . And. if the engine jumps the track or finds an insurmountable object in its. Happy those drivers who, seeing a steep. I have sometimes been asked whether I consider love higher than art, and. I have replied that I cannot separate them, for the artist is the only. Perhaps one of the most wonderful personalities of our times is Gabriel. Annunzio, and yet he is small and, except when his face lights up, can. But when he talks to one he loves, he is. Phoebus Apollo himself, and he has won. In turn he transforms. Beatrice, of whom Dante has sung in. There was an epoch in Paris when the cult of. D'Annunzio rose to such a height that he was loved by all the most. At that time he flung over each favourite in turn a. She rose above the heads of ordinary mortals and walked. But when the caprice of the poet. She herself did not know what had happened. D'Annunzio, she. realised that in all her life she would never again find this genius of. Lamenting her fate, she became more and more desolate, until. She was the. re- incarnation of the divine Beatrice herself, and over her D'Annunzio. For I have always believed that Eleanora Duse. Beatrice of Dante re- incarnated in our days, and so. D'Annunzio could only fall upon his knees in adoration, which. In all other women. Eleanora soared. above him, revealing to him the divine inspiration. How little do people know of the power of subtle flattery! To hear. oneself praised with that magic peculiar to D'Annunzio is, I imagine. Eve when she heard the voice of the. Paradise. D'Annunzio can make any woman feel that she is the. I remember a wonderful walk I had with him in the For. We stopped in. our walk and there was silence. Then D'Annunzio exclaimed, . All other women. destroy the landscape, you alone become part of it. He made each woman feel she was a. Lying here on my bed at the Negresco, I try to analyse this thing that. I feel the heat of the sun of the Midi. I hear the. voices of children playing in a neighbouring park. I feel the warmth of. I look down on my bare legs—stretching them out. The. softness of my breasts, my arms that are never still but continually. I realise that for twelve years I. I am alone these. The tears have flowed for twelve years, since that. I was suddenly. awakened by a great cry and, turning, saw L. But I could not. understand. I spoke to him very softly; I tried to calm him; I told him. Then other people came, but I could not conceive. Then entered a man with a dark beard. I was told he. was a Doctor. I wanted to go with him but people held me back. I know. since that this was because they did not wish me to know that there was. They feared the shock would make me insane, but I was. I saw every one about me. I did not weep. On the contrary I felt an immense desire to. Looking back, it is difficult for me to understand my. Was it that I was really in a state of. I knew that death does not exist—that those two. That the souls of my children lived on in radiance. Only twice comes that cry of the mother which one. Birth and at Death—for when I felt in. I heard my cries—the same cries as I had heard at their births. Why. the same—since one is the cry of supreme joy and the other of Sorrow? I. do not know why but I know they are the same. Is it that in all the. Universe there is but one Great Cry containing Sorrow, Joy, Ecstasy. Agony, the Mother Cry of Creation? MY LIFECHAPTER ONEThe character of a child is already plain, even in its mother's womb. She could take no food except iced oysters and iced. If people ask me when I began to dance I reply, . And in fact from the moment I was. I began to agitate my arms and legs in such a fury. I remember being thrown into the arms of a. I must have been about two or three. I distinctly remember the comforting feeling, among all. He must have been an. Irishman. I hear my mother cry in frenzy, . Afterwards I remember finding. I was born by the sea, and I have noticed that all the great events of. My first idea of movement, of the. I was born under the. Aphrodite, Aphrodite who was also born on the sea, and when her. At these. epochs life flows lightly and I am able to create. I have also noticed. The science of astrology has not perhaps the importance to- day that. Egyptians or of the Chaldeans, but it. I believe, too, that it must make a great difference to a child's life. The sea has always. I have a vague feeling of. They always give me an impression of. Looking up at their tops, I do not feel. My life and my art were born of the sea. I have to be thankful that when we were young my mother was poor. She. could not afford servants or governesses for her children, and it is to. I owe the spontaneous life which I had the opportunity to. My mother was a musician and taught. I could. wander alone by the sea and follow my own fantasies. How I pity the. children I see constantly attended by nurses and governesses, constantly. What chance of life. My mother was too busy to think of any dangers which might. I were free to. follow our own vagabond impulses, which sometimes led us into adventures. Fortunately she was blissfully unconscious. I say fortunately. I owe the inspiration of the dance I created, which was. I was never subjected to the continual. I think my mother. It was necessary to have some place to leave. I believe that whatever one is to do in one's after life is clearly. I was already a dancer and a revolutionist. My. mother, who had been baptised and raised in an Irish Catholic family. Catholic up to the time when she discovered that my father. She. divorced him and left with her four children to face the world. From. that time her faith in the Catholic religion revolted violently to. Bob Ingersoll, whose. Among other things, she decided that all sentimentality was nonsense. I was quite a baby she revealed to us the secret of Santa. Claus, with the result that at a school festival for Christmas, when the. The. teacher unwisely flew into a temper and, to make an example of me. I came forward, and. I made the first of my famous speeches. After failing in. I stood there, I turned. Pyrrolizidine alkaloids (EHC 8. INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY. ENVIRONMENTAL HEALTH CRITERIA 8. PYRROLIZIDINE ALKALOIDS. This report contains the collective views of an international group of. World Health Organization or the United Nations. Environment Programme. Published under the joint sponsorship of. United Nations Environment Programme. World Health Organization. World Health Organization. Geneva 1. 98. 8. ISBN 9. World Health Organization 1. Publications of the World Health Organization enjoy copyright. Protocol 2 of the. Universal Copyright Convention. For rights of reproduction or. WHO publications, in part or in toto, application. Office of Publications, World Health. Organization, Geneva, Switzerland. The World Health Organization. Errors and omissions excepted, the names of. SUMMARY AND RECOMMENDATIONS1. Sources and chemical structure. Mechanisms and features of toxicity. Nature and extent of health risks. Methods for prevention. General recommendations. Recommendations for research. PROPERTIES AND ANALYTICAL METHODS2. Chemical structure and properties. Analytical methods. Extraction. 2. 2. Plant tissue. 2. 2. Biological fluids and tissues. Analysis for pyrrolizidine alkaloids. Thin- layer chromatography (TLC). High- performance liquid chromatography. HPLC). 2. 2. 2. 3 Gas chromatography (GC) and mass. MS). 2. 2. 2. 4 Nuclear magnetic resonance (NMR). The Ehrlich reaction. Indicator dyes. 2. Direct weighing. 2. Determination of metabolites in animal tissues. SOURCES AND PATHWAYS OF EXPOSURE3. Hepatotoxic pyrrolizidine alkaloids and their sources. Pneumotoxic and other toxic pyrrolizidine alkaloids 3. Pathways of exposure. Contamination of staple food crops. Herbal infusions. Use of PA- containing plants as food. Contaminated honey. Use of PAs as chemotherapeutic agents for cancer. Absorption, excretion, and tissue distribution. Excretion and distribution. Metabolic routes. Conversion to pyrrolic metabolites. Effects of treatments affecting metabolism. Other factors affecting metabolism. Other metabolic routes. Metabolism of pyrrolizidine N- oxides. MECHANISMS OF TOXICITY AND OTHER BIOLOGICAL ACTIONS5. Metabolites responsible for toxicity. Metabolic basis of toxicity. Isolation of pyrrolic metabolites. Chemical aspects of pyrrolic metabolites. Preparation. 5. 1. Chemistry associated with toxic actions. Possible further metabolites. Toxic actions of pyrrolic metabolites. Animals. 5. 2. 1. Pyrrolic esters (dehydro- alkaloids). Pyrrolic alcohols (dehydro- necines). Possible participation of membrane lipid. Chemical and metabolic factors affecting toxicity. Structural features of a toxic alkaloid. Activation and detoxication. Factors affecting the toxicity of active. Reactivity of the metabolite. The number of reactive groups. Metabolites associated with the biological actions of. Acute hepatotoxicity. Chronic hepatotoxicity. Toxicity in other tissues. Antitumour activity. Prevention and treatment of pyrrolizidine poisoning. Pre- treatment to enhance the detoxication of active. EFFECTS ON ANIMALS6. Patterns of disease caused by different plant genera and. Field observations - outbreaks in farm animals. Studies on farm animals. Experimental animal studies. Effects on the liver. Relative hepatotoxicity of different PAs. N- oxides. 6. 4. 1. Factors affecting hepatotoxicity. Acute effects. 6. Mechanism of toxic action. Chronic effects. 6. Effects on the lungs. Acute effects. 6. Chronic effects. 6. Mechanisms of toxic action. Effects on the central nervous system. Effects on other organs. Mutagenicity. 6. 4. Chromosome damage. Carcinogenesis. 6. Purified alkaloids. Plant materials. 6. Pyrrolizidine alkaloid metabolites and. Molecular structure and carcinogenic. Antimitotic activity. Immunosuppression. Effects on mineral metabolism. Methods for the assessment of chronic. Effects on wild- life. Clinical features of veno- occlusive disease (VOD)7. Salient pathological features of veno- occlusive disease. Human case reports of veno- occlusive disease. VOD and cirrhosis of the liver. Differences between VOD and Indian childhood cirrhosis. ICC). 7. 6. Chronic lung disease. Relationship between dose level and toxic effects. Pyrrolizidine alkaloids as a chemotherapeutic agent for. Prevention of poisoning in man. EVALUATION OF HUMAN HEALTH RISKS AND EFFECTS ON THE ENVIRONMENT9. Human exposure conditions. Reported sources of human exposure. Plant species involved. Modes and pathways of exposure. Contamination of grain crops. Herbal medicines. PA- containing plants used as food and. Other food contaminated by PAs. Acute effects of exposure. Acute liver disease. Chronic effects of exposure. Cirrhosis of the liver. Mutagenicity and teratogenicity. Cancer of the liver. Effects on other organs. Effects on the environment. Soil and water. APPENDIX I. Gounar opened the meeting on behalf of the three. IPCS (UNEP/ILO/WHO). CULVENOR, assisted PROFESSOR. H. D. TANDON in the finalization of the document after the Task. Group meeting. Parizek, who was originally the IPCS staff. Secretary of the Task Group, could not attend the meeting. Task Group was assisted in his. Dr M. Gounar, former IPCS staff member. Prost was. responsible for the final version of the document. Tandon, who was. responsible for establishing such a causal relationship in the. Afghanistan and India, to prepare a draft criteria. Task Group meeting, which was held in Tashkent, USSR, on. December, 1. 98. 6. In spite of this, and the fact that. PAs have not attracted much attention in the world as. There have been reports of stray. Protein- deficient and young suckling. Schoental, 1. 95. Indeed, Stillman et al. Thus, many of the cases or even. Lancet, 1. 98. 4). Modified. seco- pyrrolizidine alkaloids, in which the central bond between the. N and C8 atoms is broken, are also hepatotoxic. Metabolites are. released into the circulation and are believed to pass beyond the. Doses of. 2. 00 mg/kg body weight resulted in intrauterine deaths or resorption. Simultaneously in non- human primates, or after a short time in. The reticulin. framework in the central zone of the lobule collapses following. A. third form of exposure, with the potential to affect large. Task Group was not. The plants involved were species of. Crotalaria, Heliotropium, Senecio, Symphytum, and Gynura. The setting of. regulatory tolerance levels for certain food products may be. Cereal crops should be assessed throughout the world for. Experimental studies should be conducted to determine. N- oxides may be. P4. 50 enzymes are involved in the activation and. N- oxidation of PAs and thence in the selective. N- oxidation enzymes. A study might be conducted of human variability and its genetic. PAs; for example, the study of mixed- function oxidase levels. Examples of some. Fig. Men'shikov and associates in Moscow in the 1. Refer also to Table 1. They were also mutagenic in. Ames system of Salmonella typhimurium and V7. Hirono et al., 1. Jacobaea jacobineb. PAsd. S. One of the dams. PA toxicity. 1. 0. Lasiocarpine 1- 1. Heliotridine 3. Heliotridine 4. From: Bull et al. Culvenor et al.. 1. Mattocks, 1. 98. 1c). N- oxide (isatinecine) using ferrous sulfate. Mattocks, 1. 96. 9). PAs, such as heliotrine and lasiocarpine. LD5. 0 (7. days) of about 2. Percy & Pierce. Hsu. et al., 1. 97. Shumaker et al., 1. Mattocks, 1. 97. 1a. Driver & Mattocks, 1. The morphological changes in the liver are similar. The milk secretion of the mothers was apparently not affected. PA treatment. Statistically significant cardiomegaly was present in all. The. readings from all the test rats were well outside the upper 9. P < 0. 0. 5) the rises in 6- keto- PGF1alpha (by 9. TXB2 (by 9. 1%) that occurred in the lung lavage of monocrotaline- . There was inhibition of crypt cell mitosis. In column 8, animals developing a tumour out of. Animals developing more than one tumour are. Different terms have been used in different studies to describe the same tumour in the liver. George- Grambauer. Rac (1. 96. 2) reported a similar outbreak of fatal jaundice due to. Echium plantagineum over 2 or more seasons. Methods for the assessment of chronic hepatotoxicity and. Pyrrolizidine alkaloids produce acute as well as chronic liver. Riedl, which had been growing profusely among. The basal ganglia showed kernicterus. No. 4. who was asymptomatic. No. 1, who. survived. Heliotrine variousd 0. VOD, Mohabbat et al. Heliotrine (a) 2. Datta et al. Riddelline, 0. VOD Stillman et al. Riddelline, 0. 1. Fox et al. Crotananine, variousd 0. VOD, Tandon, B. N. Heliotrine (a) 2. VOD Kumana et al. Echimidine 4. 9 0. VOD Ridker et al. In an. experimental situation in which cows were fed Senecio jacobaea. Cancer. Institute. Nat. Cancer. Institute. Svoboda &. 4 weeks and 1/week for then 1. Reddy (1. 97. 2). Rao & Reddy. (1. Culvenor &. to death Jago (1. Monocrotaline (a) 2. Newberne &. 4 weeks, and 8 mg/kg, then 1. Rogers (1. 97. 3). Shumaker et. 2 weeks for 5. A more quantitative assessment is not possible on the basis. Task Group stressed the need. Microbiol.,2. 1: 2. Med., 1. 04. 4. 34- 4. Pharmacol.,2. 3: 4. Chromatogr.,1. 66: 5. Pathol.,5. 3. 1. 45- 1. Ethnopharmacol.,4: 1. Planta Med.,4. 2: 2. Bacteriol.,8. 8: 5. Bacteriol.,9. 0: 1. Chromatogr.,3. 49: 2. Med.,2. 8. 5. 7- 6. Russian). Bacteriol.,8. Soc.,C1. 96. 5: 2. Fine. structure in Jamaican children. Pharmacol.,8. 5. 4. Bacteriol.,7. 8: 4. Heliotropium. poisoning of sheep. Edinburgh,B6. 6: 1. Acute liver damage in the male fowl and the. Endocrinol.,1. 5: 3. Oestrogen- induced regeneration of the chronically. Endocrinol.,1. 5: 3. Chromatogr.,2. 0: 2. Hepatotoxic alkaloids. Pharmacol.,2. 6: 3. Res., 3. 4. 1. 57. Pharmacol.,8: 5. 67- 5. Nature (Lond.),1. Res., 3. 2. 3. 61- 1. A pediatric. oncology group study. A comparison with dose rates causing tumours. Preparation and reactions of. Chem.,2. 3. 1. 85. Manganese dioxide oxidation of. Interact.,1. 2: 2. Marginal toxic effects. Merino wethers from long- term feeding. Res.,3. 5. 2. 93- 3. India, 2. 6(5): 3. Bacteriol.,4. 0: 2. Dis.,1. 0: 1. 66- 1. DEINZER, M. L., THOMSON, P. A., BURGETT, D. M., & ISAACSON, D.
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